About me
RESEARCH INTERESTS
Regenerative medicine, transdifferentiation, reprogramming, stem cell biology, mesenchymal stem cells, and systems biology
EDUCATION
NATIONAL TAIWAN UNIVERSITY (NTU) Taipei, Taiwan, R.O.C.
Ph.D. in Genome and Systems Biology Degree Program, co-contributed by National Taiwan University (NTU) and Academia Sinica September 2012 - 2017
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Advisor: Dr. Jean Lu (wet lab in Academia Sinica) and Dr. Hsiao-Chun Huang (dry lab in NTU)
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Research topic 1, Cellular reprogramming, generating chemically induced multipotent cells and neural lineage cells by small molecules
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Research topic 2, Spindle scaling and orientation in normal and cancer cells
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Research topic 3, Computational modeling for cell fate determination
TAIPEI MEDICAL UNIVERSITY (TMU) Taipei, Taiwan, R.O.C.
Master in Biomaterials and Tissue engineering August 2007 – September 2009
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Advisor: Dr. Win-Ping Deng
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Research topic 1: The Effects of Platelet-rich Plasma on IL-1b/TNF-a-induced human arthritis
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Research topic 2: Cancer reversion by traditional Chinese herb medicine
PROFESSIONAL EXPERIENC
POSTDOTORAL FELLOW
Stem Cell Program, Genomics Research Center, Academia Sinica July 2017 – present
TEACHING ASSISTANT Taipei, Taiwan, R.O.C.
Teaching course at National Taiwan University (NTU) August 2014 – June 2017
103-1 Graduate student seminar
103-2 Seminar in Genome and Systems Biology
104-1 Topics and Seminars in Genome and Systems Biology
104-2 Graduate student seminar
105-1 Graduate student seminar
105-2 Seminar in Genome and Systems Biology
GRADUATE RESEARCH ASSISTANT Taipei, Taiwan, R.O.C.
Institute of Biochemistry, Academia Sinica September 2010 - 2012
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Mentor: Dr. Guang-Chao Chen
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Research topic: Functional analysis of PTPs in development and human diseases
UNDERGRADUATE RESEARCH ASSISTANT Taipei, Taiwan, R.O.C.
Institute of Biomaterials and Tissue Engineering, Taipei Medical University September 2008 - July 2009
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Advisor: Dr. Win-Ping Deng
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Research in the treatment of human arthritis, cartilage regeneration, and mesenchymal stem cells
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Creation the ex-vivo culture system of intervertebral disc
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Clinic: A Phase II Study to Evaluate Efficacy and Safety of Using Platelet-Rich Plasma in Patients with Human Intervertebral Disc Regeneration (NSC99-3114-B038-001)
PUBLICATIONS
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Pei-Lun Lai, Hsuan Lin, Shang-Fu Chen, Shang-Chih Yang, Kuo-Hsuan Hung, Ching-Fang Chang, Hsiang-Yi Chang, Frank Leigh Lu, Yi-Hsuan Lee, Yu-Chuan Liu , Hsiao-Chun Huang, and Jean Lu. (2017) Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts. Scientific Reports 7, 44534.
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Pei-Lun Lai, Chi-Hou Ng, Shang-Fu Chen, Hsiang-Yi Chang, Hsiao-Chun Huang, and Jean Lu. Chemical reprogramming of human fibroblasts to oligodendrocyte-lineage cells. (Manuscript in preparation)
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Ching-Feng Yang, Wan-Yu Tsai, Wei-An Chen, Kai-Wen Liang, Cheng-Ju Pan, Pei-Lun Lai, Pan-Chyr Yang and Hsiao-Chun Huang. (2016) Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis. Scientific Reports 6, 35767.
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MY Li, Pei-Lun Lai, YT Chou, AP Chi, Mi YZ, KH Khoo, GD Chang, CW Wu, TC Meng and GC Chen (2015) Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Oncogene. 34, 3791-3803.
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Dong-Yuan Chen, Meng-Yen Li, Shih-Yun Wu, Yu-Ling Lin, Sung-Po Tsai, Pei-Lun Lai, Yu-Tsen Lin, Jean-Cheng Kuo, Tzu-Ching Meng, Guang-Chao Chen. (2012) The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J Cell Sci. 125, 4841-4852.
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Chia-Che Wu, Wei-Hong Chen, Bin Zao, Pei-Lun Lai, Tzu-Chieh Lin, Hung-Yao Lo, Ying-Hua Shieh, Chih-Hsiung Wu and Win-Ping Deng. (2011) Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis. Biomaterials. 32, 5847-5854. (cited 54 times, Web of Science)
PATENT
1. Method for preparing induced Mesenchymal Stem Cells and its applications
HONORS AND AWARDS
2017 Travel Award in 13th Annual meeting of Taiwan Society for Stem Cell Research (TSSCR), Taipei, Taiwan.
2017 The Dean Award, Certificate of Award, college of Life Science, National Taiwan University
2017 Award of the Phi Tau Phi Scholastic Honor Society of the Republic of China (中華民國斐陶斐獎)
2017 Gwo Xi Poster Award in 10th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC), Hualien, Taiwan (given with USD 3,000 and a plaque).
2016 Graduated Scholarship of Han-Ru Cultural and Educational Foundation, Taipei, Taiwan.
2015 Graduated Scholarship of Han-Ru Cultural and Educational Foundation in Taipei, Taiwan.
2014 Graduated Scholarship of Han-Ru Cultural and Educational Foundation in Taipei, Taiwan.
2012 Poster Award in 27th Joint Annual Conference of Biomedical Science, Taipei, Taiwan.
2009 Poster Award in Joint Academic Research Symposium, Taipei Medical University, Taipei, Taiwan.
2008 Graduated Scholarship of Lee-Ming Culture Foundation in Taipei, Taiwan.
CONFERENCE PRESENTATIONS
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Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts. 2017 Annual meeting of International Society for Stem Cell Research (ISSCR), Boston, U.S.A.
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Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts.10th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC), Hualien, Taiwan
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Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts. Pei-Lun Lai, Hsuan Lin, Shang-Fu Chen, Hsiao-Chun Huang, and Jean Lu. 12th Annual meeting of Taiwan Society for Stem Cell Research, Taichung, Taiwan.
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Optimized Approaches for Conversion Induced Mesenchymal Stem Cells from Human Fibroblasts with Small Molecules. Shang-Fu Chen, Pei-Lun Lai , Hsiao-Chun Huang, and Jean Lu. 12th Annual meeting of Taiwan Society for Stem Cell Research, Taichung, Taiwan.
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A novel role of PTPMEG/PTPN3 in EGFR signaling. MY Li, Pei-Lun Lai, AP Chi, YT Chou, KH Khoo, GD Chang, TC Meng, CW Wu, and GC Chen. 27th Joint Annual Conference of Biomedical Science, Taipei, Taiwan.
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Regeneration of Human Articular Chondrocytes in Arthritis Using Platelet-rich Plasma. Pei-Lun Lai, Wei-Hong Chen, Tzu-Chieh Lin, and Win-Ping Deng. Joint Academic Research Symposium, Taipei Medical University, Taipei, Taiwan.
ACADEMIC ACTIVITY
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2014-2015, Vice President of Student Union in Genome and Systems Biology, National Taiwan University, Taipei, Taiwan.
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2016-present, Associate Member, Taiwan Society for Stem Cell Research
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2017-present, Trainee Member, International Society for Stem Cell Research
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2017-present, Associate Member, Taiwan Society for Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC)
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2017-Honorary Member of Phi Tau Phi Scholastic reputation
SPEAKING CALENDAR
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Product: Dos & Don'ts
Backford Hall, San Francisco, CA
Fund Your Start-Up
Mission Convention Center, Austin, TX
Product Strategy
Rural College, Boston, MA
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PAST & PRESENT
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I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font. I’m a great place for you to tell a story and let your users know a little more about you.
I'm a paragraph. Click here to add your own text and edit me. It’s easy. Just click “Edit Text” or double click me to add your own content and make changes to the font.